Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure
Chunxiao Zhao, Jiahao Liu, Juanjuan Xin, Qun Liu, Ying Zhang, Xiaochun Yu, Junhong Gao · 2026
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Description
Chunxiao Zhao and co-authors review calcium mishandling in the failing heart in a 2026 paper. Each heartbeat is a calcium story: ions flood in to trigger contraction, then are pumped away for relaxation. In heart failure that cycle breaks down, and overload poisons the cell.
The review walks the machinery in three layers: release channels, the storehouse pump that refills the cell's calcium vault, and helper exchangers and gates. Two nerve receptors that tune the whole loop get their due. Drugs and gene therapies aimed at single parts are weighed, along with why single targets stall in translation. Restoring balance, not just boosting force, is the authors' thesis.
Catalog record
| CREATOR | Chunxiao Zhao, Jiahao Liu, Juanjuan Xin, Qun Liu, Ying Zhang, Xiaochun Yu, Junhong Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |