Evaluating the Anticancer and Anti‐Angiogenic Efficacy of Bergaptol in 2D and 3D Tumor Microtissue Models
Buse Bekar, Handan Sevim Akan · 2026
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Description
Buse Bekar and Handan Sevim Akan test a plant compound against cancer in this 2026 study. The compound, bergaptol, belongs to a family found in plants such as figs and citrus. The team treated three cancer cell lines, from breast, liver, and cervix, plus vessel-lining cells, and used healthy skin cells as the comparison group.
Bergaptol killed cancer and vessel cells selectively, sparing the healthy cells. Treated cells died by the cell's self-destruct path and their division cycles stalled. In three-dimensional tumor balls, the compound shrank the balls and cut their vessel cell content. A test on chick embryo membranes confirmed fewer new vessels formed. The authors argue the dual action, against tumors and against their blood supply, merits further study.
Catalog record
| CREATOR | Buse Bekar, Handan Sevim Akan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |