The Impact of BOLD‐Induced Linewidth Modulation on Functional 1H MRS Analysis
Martin Wilson, Simon M. Finney, William T. Clarke · 2026
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Description
Martin Wilson and two colleagues examine a hidden bias in functional MRS, a scan method that tracks brain chemicals while the brain works. When an area wakes up, blood flow shifts, an effect known as BOLD, and that shift slightly narrows spectral lines. Narrower lines can masquerade as a true rise in a chemical. The team used synthetic scan data to test fitting tools at two scanner strengths.
Both standard tools showed a bias near one percent for glutamate, matching earlier lab work, and newer 2D tools fared no better. Adding a step that matches line width to the BOLD state cut the bias to under a fifth of a percent. Wilson and the team urge that step for all such studies at 3 Tesla and above.
Catalog record
| CREATOR | Martin Wilson, Simon M. Finney, William T. Clarke |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |