Strontium ameliorates tibial dyschondroplasia in broilers through gut microbiota-mediated retinoic acid metabolism
Shu-cheng Huang, Bo-wen Xu, Ya-nan Lu, Tao-jing Yue, Wen-li Ding, Fang-fang Guo, Zi-qun Zhang, Xi-shuai Tong, Cai Zhang, Li Wang · 2026
Read Strontium ameliorates tibial dyschondroplasia in broilers through gut microbiota-mediated retinoic acid metabolism by Shu-cheng Huang, Bo-wen Xu, Ya-nan Lu, Tao-jing Yue, Wen-li Ding, Fang-fang Guo, Zi-qun Zhang, Xi-shuai Tong, Cai Zhang, Li Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13590495.txt.
Description
Shu-cheng Huang and colleagues showed that dietary strontium eases tibial dyschondroplasia in broilers through the gut-bone axis. This leg disorder plagues fast-growing broilers, harming welfare and production, and strontium's bone benefits were known but its gut-mediated mechanism was not. Their 2026 study fed affected broilers 200 milligrams of strontium per kilogram of feed and tracked bones, gut microbes, and metabolites.
Strontium restored tibial microstructure, corrected blood calcium and phosphorus, aligned cartilage cells, raised bone density and blood-vessel growth, and switched on bone-building pathways while suppressing bone-resorbing RANKL signals. It also reshaped gut microbes, boosting Pediococcus pentosaceus and cutting Levilactobacillus brevis, changes tied to lower levels of the bone-harming metabolite 9-cis-retinoic acid. Added retinoic acid worsened disease, while strontium co-treatment blunted that harm.
Catalog record
| CREATOR | Shu-cheng Huang, Bo-wen Xu, Ya-nan Lu, Tao-jing Yue, Wen-li Ding, Fang-fang Guo, Zi-qun Zhang, Xi-shuai Tong, Cai Zhang, Li Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |