Peripheral Blood Transcriptomic Features Distinguishing Postpartum Depression from Major Depressive Disorder and Healthy Postpartum Controls
Lvping Lin, Han Tang, Hongjun Kuang, Yunhong Yang, Hong Zhao · 2026
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Description
Lvping Lin and co-authors compare blood gene patterns across postpartum depression, regular major depression, and healthy new mothers in a 2026 study. The illness after birth is common but its biology blurs with regular depression. Forty-seven women gave blood cells for transcriptome sequencing.
Hundreds of genes varied in each contrast, in exploratory analysis. The postpartum signature showed thrown-off antibody immunity, upset folate handling, and wear on the blood-brain barrier's matrix. One folate gene fell hardest; two others rose against both other groups. Against the regular kind, microbe-contact switches flipped on while brain growth signals dimmed. The pattern paints postpartum depression as its own distinct kind.
Catalog record
| CREATOR | Lvping Lin, Han Tang, Hongjun Kuang, Yunhong Yang, Hong Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |