Structural Prerequisites for Pim-1 Kinase Inhibition and the Identification of a Pyrazolyl-Methylene-Indolinone Hit
Rufaida Al Zoubi, Omar Hadieh, Soraya Alnabulsi, Israa H Isawi, Shubin Liu · 2026
Read Structural Prerequisites for Pim-1 Kinase Inhibition and the Identification of a Pyrazolyl-Methylene-Indolinone Hit by Rufaida Al Zoubi, Omar Hadieh, Soraya Alnabulsi, Israa H Isawi, Shubin Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13590258.txt.
Description
Pim-1 is a protein that helps some cancer cells grow, and blocking it is a goal for new drug design. Rufaida Al Zoubi and co-authors, writing in 2026, searched for fresh compounds that can block this protein. They screened close to nine hundred thousand compounds on the computer, then tested six of them in the lab.
One tested compound, built on a shape not reported for this target before, blocked Pim-1 at a modest strength. Further computer work showed why some high-scoring compounds failed in the lab: their flat shapes were hard to reach in real terms of energy. The active compound also formed two key links with parts of the protein. The hit gives drug designers a new starting shape to improve.
Catalog record
| CREATOR | Rufaida Al Zoubi, Omar Hadieh, Soraya Alnabulsi, Israa H Isawi, Shubin Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |