The Dual Role of Exosome-Mediated Central-Peripheral Immune Dialogue in Amyotrophic Lateral Sclerosis-Associated Neuroinflammation
Tao Jin, Bingjie Yang, Zhuoyuan Cai, Hao Zhang, Ting Wang · 2026
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Description
Tao Jin and co-authors weigh evidence that exosomes ferry immune messages between brain and body in ALS. Exosomes are tiny sacs cells shed to signal each other. ALS is now seen as a whole-body disease, not a brain-only one. Their 2026 review grades the proof into tiers: human ALS data, ALS cell and animal work, other brain inflammation models, and background reviews. The tiers keep strong claims honest.
Human studies find ALS-linked proteins and shifted small RNAs in blood sacs. Where the sacs start and what they cause stay unclear. Animal work hints the sacs move proteins and tune glial behavior. Some star mechanisms come from other diseases and count as guesses. The team urges care before therapy talk.
Catalog record
| CREATOR | Tao Jin, Bingjie Yang, Zhuoyuan Cai, Hao Zhang, Ting Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |