A coordinated shift toward a macrocytic and hypochromic erythrocyte phenotype in adults with neurofibromatosis type 1
Yoshimasa Nobeyama, Satoko Imai, Akihiko Asahina · 2026
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Description
Yoshimasa Nobeyama, Satoko Imai, and Akihiko Asahina present a 2026 study of red blood cell traits in adults with neurofibromatosis type 1. The genetic disorder touches many body systems, but its blood traits are little charted. The team asked whether red cell measures shift together in a set pattern.
Records from 225 adults at one institute were scored against a reference population. Cell count, hemoglobin, and cell volume ran modestly high, while hemoglobin density shifted the other way. Solo effects were small, but a pooled score showed a clear joint shift with a moderate effect size. Higher tumor burden tied to lower hemoglobin density. The pattern reads as larger, paler red cells as a group trait.
Catalog record
| CREATOR | Yoshimasa Nobeyama, Satoko Imai, Akihiko Asahina |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |