Biomaterial engineering of the tumor glycocalyx for cancer immunotherapy
Zhiyu Guo, Xu Chen, Guiye Wu, Zili Chen, Jinhong Wu, Zihao Zhou, Rongwei Xu, Meiyan Zou, Nina Li, Weiyao Feng, Xinyuan Zhao, Zhiping Wang, Li Cui · 2026
Read Biomaterial engineering of the tumor glycocalyx for cancer immunotherapy by Zhiyu Guo, Xu Chen, Guiye Wu, Zili Chen, Jinhong Wu, Zihao Zhou, Rongwei Xu, Meiyan Zou, Nina Li, Weiyao Feng, Xinyuan Zhao, Zhiping Wang, Li Cui (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13590086.txt.
Description
Zhiyu Guo and twelve co-authors review how engineered materials can remodel the sugar coat of tumors in a 2026 paper. The glycocalyx, a sugary layer on cell surfaces, helps cancers hide from the immune system: extra sialic acids, stunted sugar chains, and mucin barriers all blunt immune attack. Those same features, though, are handles for therapy.
The review catalogs material tools: nanoparticles, sugar polymers, enzyme carriers, vesicles, gels, and synthetic surface parts. They can cut sugar production, strip sialic acids, break mucin walls, or install targeting cues, and they can jam immune checkpoints built on sugar recognition. The authors then list the hard problems, from tumor variety to damage of healthy sugars, that keep the approach from the clinic.
Catalog record
| CREATOR | Zhiyu Guo, Xu Chen, Guiye Wu, Zili Chen, Jinhong Wu, Zihao Zhou, Rongwei Xu, Meiyan Zou, Nina Li, Weiyao Feng, Xinyuan Zhao, Zhiping Wang, Li Cui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |