Unmasking phenotypic heterogeneity and extracellular matrix architecture in neuroblastoma through orthotopic xenograft modeling
Meryem El Ouardi, Isaac Vieco-Martí, Sofía Granados-Aparici, Inmaculada Noguera, Samuel Navarro, Rosa Noguera · 2026
Read Unmasking phenotypic heterogeneity and extracellular matrix architecture in neuroblastoma through orthotopic xenograft modeling by Meryem El Ouardi, Isaac Vieco-Martí, Sofía Granados-Aparici, Inmaculada Noguera, Samuel Navarro, Rosa Noguera (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13590057.txt.
Description
Meryem El Ouardi and co-authors grow a childhood nerve tumor in mice to watch its variety up close. Their 2026 paper studies neuroblastoma, a cancer whose cells swing between states and resist treatment. The mesh around the cells, the extracellular matrix, shapes that swinging, yet its dance with cell identity was hard to trace.
The team tracked a marker of nerve-like state across several models. Even marker-positive tumors hid pockets where it vanished. Tumor grafts grown at the natural site, from flat cultures and from gel-grown balls, let them compare cell and matrix together. A common lab line formed grafts with mixed, plastic zones wrapped in a dense aligned fiber net, unlike the poorly sorted original tumors. Digital analysis maps the contrast.
Catalog record
| CREATOR | Meryem El Ouardi, Isaac Vieco-Martí, Sofía Granados-Aparici, Inmaculada Noguera, Samuel Navarro, Rosa Noguera |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |