Metastatic immune microenvironment remodeling by malignant epithelial cells drives colorectal cancer hepatic metastasis: Multi-omics insights
Wenlong Zhu, Ao Dong, Rongbing Hu, Silei Zhou, Jiali Yao, Binghua Ma, Jin Ding, Yanjie Zhang · 2026
Read Metastatic immune microenvironment remodeling by malignant epithelial cells drives colorectal cancer hepatic metastasis: Multi-omics insights by Wenlong Zhu, Ao Dong, Rongbing Hu, Silei Zhou, Jiali Yao, Binghua Ma, Jin Ding, Yanjie Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13590056.txt.
Description
Zhu and co-authors use multi-omics data to show how colon cancer cells that reach the liver reshape the immune scene there, in this 2026 study. Spread to the liver is common in advanced colorectal cancer and hard to treat. Cancerous surface cells sit at the core of that spread, yet their role was murky.
A tool that links cell traits to patient outcomes picked out a distinct group of malignant cells. Three genes formed a risk score: higher scores meant worse outlooks. These cells were found to call in suppressive immune cells and convert ordinary defenders into tumor-friendly ones. Lab assays checked parts of the story. The authors name pathways that new drugs might block.
Catalog record
| CREATOR | Wenlong Zhu, Ao Dong, Rongbing Hu, Silei Zhou, Jiali Yao, Binghua Ma, Jin Ding, Yanjie Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |