eNAMPT-IFITM3 axis links neuroinflammation to γ-secretase activation
Junho Hyun, Sunmin Jung, Yoona Noh, Yeonsu Cho, Takaomi C. Saido, Jihoon Nah, Ki Woo Kim, Yong-Keun Jung · 2026
Read eNAMPT-IFITM3 axis links neuroinflammation to γ-secretase activation by Junho Hyun, Sunmin Jung, Yoona Noh, Yeonsu Cho, Takaomi C. Saido, Jihoon Nah, Ki Woo Kim, Yong-Keun Jung (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13590055.txt.
Description
Junho Hyun and colleagues report a two thousand twenty-six study linking brain inflammation to the enzyme complex that makes amyloid in Alzheimer's disease. Amyloid build-up and inflammation are both central, but their connecting machinery was unclear. A screening hunt found the link.
A metabolic enzyme released outside cells latched onto a surface protein on other cells. That grip stabilized the protein and helped assemble the amyloid-making complex. Levels of the enzyme ran high in patient and mouse brains. Body-wide inflammation strengthened the interaction in living mice. An antibody blocking the enzyme calmed the effect, naming a drug target.
Catalog record
| CREATOR | Junho Hyun, Sunmin Jung, Yoona Noh, Yeonsu Cho, Takaomi C. Saido, Jihoon Nah, Ki Woo Kim, Yong-Keun Jung |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |