Transcriptomic trajectory of hepatocyte ballooning reveals a lipotoxic point of no return and initiates oncogenic regulatory rewiring in MASLD
Debopriyo Ganguly, Bandana Mondal, Subhas Das, Indrashish Dey, Ayan Mandal, Trinath Ghosh, Monalisha Deo, Misba Ahmed, Soma Banerjee, Ankita Chatterjee, Priyadarshi Basu · 2026
Read Transcriptomic trajectory of hepatocyte ballooning reveals a lipotoxic point of no return and initiates oncogenic regulatory rewiring in MASLD by Debopriyo Ganguly, Bandana Mondal, Subhas Das, Indrashish Dey, Ayan Mandal, Trinath Ghosh, Monalisha Deo, Misba Ahmed, Soma Banerjee, Ankita Chatterjee, Priyadarshi Basu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13590054.txt.
Description
Debopriyo Ganguly and ten co-authors trace the molecular path of liver cell ballooning in fatty liver disease in this 2026 paper. Ballooned liver cells mark the turn toward severe steatohepatitis, but their biology was murky. The team combined patient liver data, a single nucleus atlas of over eighty-seven thousand liver cells, and machine learning. An eight gene signature marked ballooned cells and separated moderate to severe ballooning from none. Six genes formed an injury score that peaked in scarred, cirrhotic livers.
Cell timeline analysis showed a four stage collapse. A chromatin stabilizer was lost, stress genes took over, and the normal liver program shut down. Ballooned cells sent scar promoting signals to neighboring support and immune cells. Three signature genes also predicted worse survival in liver cancer. The authors describe a lipotoxic point of no return along the path.
Catalog record
| CREATOR | Debopriyo Ganguly, Bandana Mondal, Subhas Das, Indrashish Dey, Ayan Mandal, Trinath Ghosh, Monalisha Deo, Misba Ahmed, Soma Banerjee, Ankita Chatterjee, Priyadarshi Basu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |