Acrylamide-associated gastric cancer progression involves RRM2-related nucleotide metabolic dysregulation and immune evasion
Peiru Si, Tianlong Zhang, Xuefeng Lv · 2026
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Description
Peiru Si, Tianlong Zhang, and Xuefeng Lv published a study in 2026 on how acrylamide, a widespread contaminant and probable carcinogen, may feed stomach cancer growth. Its role in this cancer was unclear. Joining three databases, the team found a small set of genes linking the chemical, nucleotide metabolism, and the cancer. One gene, RRM2, stood out and was overactive in tumor tissue.
Lab assays showed that gene drives cell growth and invasion and cuts cell death. A learning model built around it split patients into risk groups with distinct drug response patterns. Single-cell data showed stronger signaling between high-score tumor cells and immune cells. The authors name the gene a candidate target, pending direct proof.
Catalog record
| CREATOR | Peiru Si, Tianlong Zhang, Xuefeng Lv |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |