Breaking the Feedback Loop: A Model of Vicious Cycle for CIPN and Acupuncture-Medication Combination
Jiajing Wang, Yifei Guo, Jiao Gou, Xuan Liu, Xiaorui Wang, Chenguang Yang · 2026
Read Breaking the Feedback Loop: A Model of Vicious Cycle for CIPN and Acupuncture-Medication Combination by Jiajing Wang, Yifei Guo, Jiao Gou, Xuan Liu, Xiaorui Wang, Chenguang Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13589961.txt.
Description
Jiajing Wang and co-authors model chemo nerve damage as a vicious cycle in a 2026 review. Chemotherapy-induced neuropathy brings pain, numbness, and tingling that often refuse to fade. Straight-line cause stories cannot explain why it sticks.
Their hypothesis is a loop. Drug injury hurts mitochondria and stirs oxidative stress; each worsens the other. Inflammation wakes, ion channels remodel, and neurons grow jumpy. Jumpiness feeds back into more mitochondrial damage. Most drugs hit one node of the loop, which may cap their power. Acupuncture and herbal formulas, hitting several nodes at once, might break the cycle better. The evidence is early and mixed, the authors caution.
Catalog record
| CREATOR | Jiajing Wang, Yifei Guo, Jiao Gou, Xuan Liu, Xiaorui Wang, Chenguang Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |