Substitution Patterns After Discontinuation of CNS‐Active Medications in Older Adults in Primary Care
Shelly L Gray, Annalisa V Piccorelli, Laura A Hart, Andrea J Cook, Brian D Williamson, Benjamin H Balderson, Elizabeth A Phelan · 2026
Read Substitution Patterns After Discontinuation of CNS‐Active Medications in Older Adults in Primary Care by Shelly L Gray, Annalisa V Piccorelli, Laura A Hart, Andrea J Cook, Brian D Williamson, Benjamin H Balderson, Elizabeth A Phelan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13589677.txt.
Description
Shelly L Gray and six colleagues report a 2026 study of older adults in primary care who stopped a drug that acts on the brain or nerves. Such drugs include pain opioids, sedatives, and some drugs for mood or muscle spasm. The team asked a plain question: when one drug stops, does a new one take its place? They also checked whether the new drug was one that guides warn against for older people.
Among 2,182 people, 442 target drugs were stopped, and only 42 stops led to a swap. One in four swaps still used a drug flagged as risky for this age group. Gray and the team urge clearer advice for prescribers, so that stopping one unsafe drug does not simply start another.
Catalog record
| CREATOR | Shelly L Gray, Annalisa V Piccorelli, Laura A Hart, Andrea J Cook, Brian D Williamson, Benjamin H Balderson, Elizabeth A Phelan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22245 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |