Targeting Regnase-1 in B7-H3-CAR T cells reprograms the tumor microenvironment and enhances antitumor efficacy for osteosarcoma
Adeleye O. Adeshakin, Hao Shi, S. Scott Perry, Heather Sheppard, Phuong Nguyen, Xiang Sun, Peipei Zhou, Jean-Yves Métais, Trevor Cunningham, Anil KC, Liqing Tian, Vivek Peche, Mollie S. Prater, Deanna M. Langfitt, Carla O'Reilly, Jeoungeun J. Park, Ashley Chabot, Sheng Zhou, Azusa Matsubara, GaHyun · 2026
Read Targeting Regnase-1 in B7-H3-CAR T cells reprograms the tumor microenvironment and enhances antitumor efficacy for osteosarcoma by Adeleye O. Adeshakin, Hao Shi, S. Scott Perry, Heather Sheppard, Phuong Nguyen, Xiang Sun, Peipei Zhou, Jean-Yves Métais, Trevor Cunningham, Anil KC, Liqing Tian, Vivek Peche, Mollie S. Prater, Deanna M. Langfitt, Carla O'Reilly, Jeoungeun J. Park, Ashley Chabot, Sheng Zhou, Azusa Matsubara, GaHyun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13589500.txt.
Description
Adeleye Adeshakin and co-authors test a gene edit that could strengthen cell therapy for a bone cancer in this 2026 paper. The therapy uses a patient's own T cells, reworked to hunt tumor cells. Solid tumors build a suppressive setting that blunts such cells, and osteosarcoma is a hard case.
The team deleted a brake gene, called Regnase-1, from T cells aimed at a tumor target named B7-H3. The edited cells fought tumors better in living models, in both human and mouse versions. They also reshaped the tumor's setting, drawing in more helpful immune cells and cutting suppressive ones. The authors say the edit helps both the cells themselves and the wider immune response. They nominate the product for early clinical testing in solid tumors.
Catalog record
| CREATOR | Adeleye O. Adeshakin, Hao Shi, S. Scott Perry, Heather Sheppard, Phuong Nguyen, Xiang Sun, Peipei Zhou, Jean-Yves Métais, Trevor Cunningham, Anil KC, Liqing Tian, Vivek Peche, Mollie S. Prater, Deanna M. Langfitt, Carla O'Reilly, Jeoungeun J. Park, Ashley Chabot, Sheng Zhou, Azusa Matsubara, GaHyun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 102 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |