Long-read RNA-seq maps the isoform landscape of the trigeminal ganglion in an allergic rhinitis mouse model
Zhiyao Han, Beirui Yu, Maoqia Shen, Ziyuan Tang, Xinran Li, Mingyang Wang, Fengxian Li, Xiaolong Cao · 2026
Read Long-read RNA-seq maps the isoform landscape of the trigeminal ganglion in an allergic rhinitis mouse model by Zhiyao Han, Beirui Yu, Maoqia Shen, Ziyuan Tang, Xinran Li, Mingyang Wang, Fengxian Li, Xiaolong Cao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13589356.txt.
Description
Han and colleagues build a full-length transcript map of the nerve hub behind hay fever symptoms. Their 2026 paper profiles the trigeminal ganglion, the sensory relay driving nasal itching and sneezing in allergic rhinitis, in a mouse model. Short-read sequencing fragments transcripts, so the team paired it with long-read sequencing that captures whole RNA molecules, accepting weaker counting in exchange.
They catalogued 25,988 high-confidence isoforms in full-length form. These came from over 13,000 known genes plus 237 new ones. Nearly three in ten isoforms were previously unrecorded, and alternative first exons were the commonest splicing event, especially among the novel forms. Allergic inflammation shifted gene expression, splicing, and promoter use. Adding single-cell data showed splicing patterns were strongly cell-type specific even when overall gene expression was not, suggesting splicing diversifies nerve-cell function in allergy.
Catalog record
| CREATOR | Zhiyao Han, Beirui Yu, Maoqia Shen, Ziyuan Tang, Xinran Li, Mingyang Wang, Fengxian Li, Xiaolong Cao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |