Genetic mutations within tva receptor gene confer resistance to ALV-A and ALV-K infection in chickens
Huijuan Xu, Huanqiang Chen, Meifeng Yang, Yongshen Wen, Zhixiang Kuang, Wanting Su, Sheng Chen, Qingmei Xie, Weiguo Chen · 2026
Read Genetic mutations within tva receptor gene confer resistance to ALV-A and ALV-K infection in chickens by Huijuan Xu, Huanqiang Chen, Meifeng Yang, Yongshen Wen, Zhixiang Kuang, Wanting Su, Sheng Chen, Qingmei Xie, Weiguo Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13589137.txt.
Description
Huijuan Xu and eight colleagues hunt chicken genes that slam the door on two leukosis viruses. Avian leukosis viruses cause tumors and immune damage in poultry, with no vaccine available, so breeding resistance is a prime strategy. Entry of the A and K subgroups depends on a cell receptor built by the tva gene, and six resistant versions of that gene were known. The team screened Qingyuan partridge chickens for them in their 2026 study.
Five resistant versions turned up in the breed. In cell tests, one version, tvar2, blocked both viruses completely, while the other four sharply cut the K virus's success. Live bird infections matched the dish results. The resistant versions were widespread in the breed, with some flocks carrying them at high rates. The authors offer these gene versions as ready targets for breeding programs.
Catalog record
| CREATOR | Huijuan Xu, Huanqiang Chen, Meifeng Yang, Yongshen Wen, Zhixiang Kuang, Wanting Su, Sheng Chen, Qingmei Xie, Weiguo Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |