Identification of Inflammatory Cell Death‐Related Prognostic Signature and Its Regulatory Mechanism in Lung Adenocarcinoma
Yalun Yang, Di Liu, Shengwei Ma · 2026
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Description
Yalun Yang, Di Liu, and Shengwei Ma build a risk signature for lung adenocarcinoma in a 2026 study. This common lung cancer varies widely in outcome. Cell death tied to inflammation may shape that variation, since dying cells send signals that stir the tumor's surroundings. The team hunted for the regulator genes behind those signals.
They compared gene activity in tumor data from two public sets. Twenty-four regulators of inflammatory cell death differed between tumor and normal tissue. Those genes split patients into two subtypes with different survival and immune profiles. A seven-gene risk model then sorted patients by outlook and by likely response to drugs and immune therapy. In lab tests, silencing one gene in the signature slowed cancer cell growth and movement.
Catalog record
| CREATOR | Yalun Yang, Di Liu, Shengwei Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |