ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming
Sen Yu, Mingxin Ke, Muyuan Ma, Tingting Jiang, Xiaojia Li, Keping Xie · 2027
Read ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming by Sen Yu, Mingxin Ke, Muyuan Ma, Tingting Jiang, Xiaojia Li, Keping Xie (2027) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13589071.txt.
Description
Sen Yu and five colleagues uncover a brake on pancreatic cancer hidden in a cell's sealing machinery. The protein in question, ZO-2, normally helps stitch cells together at tight junctions, and its behavior in pancreatic ductal adenocarcinoma was unknown. Their 2027 study linked patient tissue data with lab and mouse experiments to trace what happens when ZO-2 fades.
Tumors held less ZO-2 than healthy tissue, and low levels tracked aggressive disease and worse survival. Restoring ZO-2 slowed cancer cell growth and spread and shrank tumors in mice. It works by grabbing a mitochondrial protein, PGAM5, and holding it in the cell body. Without that grip, PGAM5 crowds the mitochondria and stokes their output, reactive oxygen, and energy supply, which fuels the cancer. ZO-2 levels also tracked immune cell presence. The authors nominate the pair as a drug target.
Catalog record
| CREATOR | Sen Yu, Mingxin Ke, Muyuan Ma, Tingting Jiang, Xiaojia Li, Keping Xie |
|---|---|
| YEAR | 2027 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56137 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |