Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea
Michael R. Williamson, Jorge Botas, Mahyar J. Hedayatpour, Thea Zlatkov, Akdes Serin Harmanci, Christopher J. Yates, Kenneth Nobleza, Roshan Ailani, Adam C. Adler, Farrah Kheradmand, Hyun Kyoung Lee, Benjamin Deneen · 2026
Read Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea by Michael R. Williamson, Jorge Botas, Mahyar J. Hedayatpour, Thea Zlatkov, Akdes Serin Harmanci, Christopher J. Yates, Kenneth Nobleza, Roshan Ailani, Adam C. Adler, Farrah Kheradmand, Hyun Kyoung Lee, Benjamin Deneen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13589049.txt.
Description
Michael R Williamson and colleagues hunt the brain changes behind memory trouble in childhood sleep apnea. In this condition, the airway collapses repeatedly at night, and the front-line fix, removing tonsils and adenoids, often fails to restore learning. Working in a mouse model that mirrors the illness, the team read gene activity cell by cell in the hippocampus, the brain's memory hub.
Gene programs were disturbed in every cell type, most sharply in glia, the brain's support cells, and in neural stem cells. Six genes showed matching drops at the protein level across four cell types. Insulation of nerve fibers, the myelin wrapping laid by glial cells, was measurably impaired, glial shapes looked abnormal, and stem cell numbers in their nursery zone had thinned. The authors frame glial failure as a core driver and publish the full cell atlas for others to mine.
Catalog record
| CREATOR | Michael R. Williamson, Jorge Botas, Mahyar J. Hedayatpour, Thea Zlatkov, Akdes Serin Harmanci, Christopher J. Yates, Kenneth Nobleza, Roshan Ailani, Adam C. Adler, Farrah Kheradmand, Hyun Kyoung Lee, Benjamin Deneen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |