Reprogramming M2 macrophages via TLR7/8 agonist-loaded hollow MnO2 nanovehicles to suppress the progression of liver cancer
Pei-pei He, Zheng-ju Hou, Han-mei Li, Ji-xuan Zhang, An-Qi Chen, Quan-you Miao, Chao-Feng Yang, Jin-hong Yu, Yang Li · 2026
Read Reprogramming M2 macrophages via TLR7/8 agonist-loaded hollow MnO2 nanovehicles to suppress the progression of liver cancer by Pei-pei He, Zheng-ju Hou, Han-mei Li, Ji-xuan Zhang, An-Qi Chen, Quan-you Miao, Chao-Feng Yang, Jin-hong Yu, Yang Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13588417.txt.
Description
Pei-pei He and co-authors build, in a 2026 study, a tiny vehicle that reprograms immune cells inside liver tumors. Tumors shelter macrophages of a healing type that shields the cancer. Flipping them to the fighting type is a prized goal. The team loaded a drug that wakes immune sensors into hollow manganese shells and coated the shells for stability. In the tumor's acid, rich setting, the shells break open.
In lab dishes, the system flipped the macrophages: fighting markers rose and healing markers fell. Two switch paths fired at once, which strengthened the flip. The freed manganese also lit up MRI scans, so the dose could be watched. In mice with liver tumors, shots into the tumor slowed growth by about four fifths, with no clear harm to the body.
Catalog record
| CREATOR | Pei-pei He, Zheng-ju Hou, Han-mei Li, Ji-xuan Zhang, An-Qi Chen, Quan-you Miao, Chao-Feng Yang, Jin-hong Yu, Yang Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |