A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood–brain barrier
Henrique Nogueira Pinto, Lois Kistemaker, Mikhail Ponomarenko, Arthur A. Ermakov, Manon Karsten-van Diepen, Susanne M. A. van der Pol, R. Jeroen Pasterkamp, Stephanie D. Beekhuis-Hoekstra, Nienke M. de Wit, Emma J. van Bodegraven, Helga E. de Vries, Elly M. Hol · 2026
Read A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood–brain barrier by Henrique Nogueira Pinto, Lois Kistemaker, Mikhail Ponomarenko, Arthur A. Ermakov, Manon Karsten-van Diepen, Susanne M. A. van der Pol, R. Jeroen Pasterkamp, Stephanie D. Beekhuis-Hoekstra, Nienke M. de Wit, Emma J. van Bodegraven, Helga E. de Vries, Elly M. Hol (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13588194.txt.
Description
Henrique Nogueira Pinto and colleagues link a lab-grown blood-brain barrier to a human brain organoid on a single chip. The barrier guards the brain but also blocks most medicines, and animal models mimic it poorly. Their platform grows a flow-through, vessel-like barrier from human stem cells beside an open chamber holding a mini brain organoid, joined by a gel interface with no artificial membrane in between.
The two parts coexisted stably on the chip. Star-shaped support cells from the organoid reached out, crossed toward the barrier, and touched its vessel cells directly, copying the real neurovascular unit's layout. Because both sides stay open to testing, a candidate drug's crossing and its effect on brain tissue can be read in one run. The authors offer the chip as a human-first stand-in for animal barrier studies.
Catalog record
| CREATOR | Henrique Nogueira Pinto, Lois Kistemaker, Mikhail Ponomarenko, Arthur A. Ermakov, Manon Karsten-van Diepen, Susanne M. A. van der Pol, R. Jeroen Pasterkamp, Stephanie D. Beekhuis-Hoekstra, Nienke M. de Wit, Emma J. van Bodegraven, Helga E. de Vries, Elly M. Hol |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| LICENSE | https://creativecommons.org/licenses/by/3.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |