Epigenetic training licenses naïve CD8+ T cell metabolic fitness and function
Mengjie Lv, Jiyu Ding, Haizhen Long, Qian Chai, Lili Xu, Caiwei Jin, Wei Liang, Liwei Zhang, Bangmin Zhang, Zhihan Lv, Jicheng Zhao, Guohong Li, Mingzhao Zhu · 2026
Read Epigenetic training licenses naïve CD8+ T cell metabolic fitness and function by Mengjie Lv, Jiyu Ding, Haizhen Long, Qian Chai, Lili Xu, Caiwei Jin, Wei Liang, Liwei Zhang, Bangmin Zhang, Zhihan Lv, Jicheng Zhao, Guohong Li, Mingzhao Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13588190.txt.
Description
Mengjie Lv and eleven co-authors show how resting immune cells are quietly trained for future action, in a study from 2026. Killer T cells sit idle yet must react fast when a threat appears. A histone variant placed at energy genes turns out to license that readiness.
In resting cells, the variant marks genes for cell power plants, priming them for quick switch-on. A steady hormone signal drives this training, and a control factor steers placement. With age, that signal fades, training weakens, and responses suffer, but boosting the signal or the variant restores function. Extra variant also improved engineered T cells against tumors.
Catalog record
| CREATOR | Mengjie Lv, Jiyu Ding, Haizhen Long, Qian Chai, Lili Xu, Caiwei Jin, Wei Liang, Liwei Zhang, Bangmin Zhang, Zhihan Lv, Jicheng Zhao, Guohong Li, Mingzhao Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |