An automated high-resolution screening platform identifies regulators of anchor cell invasion in C. elegans
Simon Berger, Silvan Spiri, Evelyn Lattmann, Stefanie Engleitner, Mitchell P. Levesque, Andrew deMello, Alex Hajnal · 2026
Read An automated high-resolution screening platform identifies regulators of anchor cell invasion in C. elegans by Simon Berger, Silvan Spiri, Evelyn Lattmann, Stefanie Engleitner, Mitchell P. Levesque, Andrew deMello, Alex Hajnal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13588180.txt.
Description
Simon Berger and six co-authors unveil an automated screening rig for a tiny roundworm used worldwide in biology labs, in this 2026 paper. The rig images living worms in microfluidic chips at fine detail without the fiddly handling that has held back such screens. They prove it on a study of one cell that must break through a membrane, a process much like cancer cells invading tissue.
Over forty thousand animals were imaged and scored by a custom neural network with accuracy above ninety-two percent. Silencing 193 candidate genes one by one, the screen recovered forty-one of fifty-two known invasion genes. It also flagged fifty-one new candidate regulators. The authors say the system opens fast, sharp screening to ordinary labs, for gene hunts and drug tests alike.
Catalog record
| CREATOR | Simon Berger, Silvan Spiri, Evelyn Lattmann, Stefanie Engleitner, Mitchell P. Levesque, Andrew deMello, Alex Hajnal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |