One-pot divergent synthesis of 5-arylmethyl oxazoles and polyacenes from propargylic amides and arynes
A. Yannic R. Werling, Yun Yang, Christopher R. Jones · 2026
Read One-pot divergent synthesis of 5-arylmethyl oxazoles and polyacenes from propargylic amides and arynes by A. Yannic R. Werling, Yun Yang, Christopher R. Jones (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13588082.txt.
Description
Werling, Yang, and Jones report a one-pot route to two families of useful ring compounds. Starting from simple amide building blocks, a gold catalyst first closes them into small rings. The products then meet a reactive partner called an aryne, which joins in two different ways depending on how much is added.
With modest amounts, the path yields oxazoles carrying an arylmethyl group, a scaffold found in many drug-like molecules. With excess partner, a cascade instead builds fused ring systems, ending in polyacenes after an oxygen-removal step. The whole sequence runs under mild conditions in a single vessel. Selectivity comes simply from counting the aryne dose. The authors frame the method as an easy dial for chemical diversity from one starting mix.
Catalog record
| CREATOR | A. Yannic R. Werling, Yun Yang, Christopher R. Jones |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |