Metabolomic analysis of gingival crevicular fluid for dental age and skeletal maturity assessment in growing individuals
Tsagkari Eirini, Panteris Eleftherios, Papadopoulos A Moschos, Chatzigianni Athina · 2026
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Description
Tsagkari and colleagues explore in 2026 whether the fluid that seeps from the gum margin can reveal how a young patient's teeth and skeleton are maturing. Such biomarkers could help orthodontists time treatment to growth.
The team collected gingival crevicular fluid from 54 young patients and profiled its small molecules with gas chromatography-mass spectrometry, an untargeted method that catalogs whatever chemistry is present. Dental development was scored from X-rays by the Demirjian method and skeletal maturity from neck vertebrae shape. Of 63 compounds found, two stood out for dental age: cadaverine and the amino acid valine. Both rose during tooth development and fell in late stages, while two acids declined as dental age advanced. Cadaverine plus two other amino-acid relatives tracked skeletal maturation strongly. The authors call for broader profiling to confirm the signals.
Catalog record
| CREATOR | Tsagkari Eirini, Panteris Eleftherios, Papadopoulos A Moschos, Chatzigianni Athina |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |