Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond
Lucius K Wilmerding, Fox Gourianova, Christine Grienberger · 2026
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Description
Lucius Wilmerding, Fox Gourianova, and Christine Grienberger review a fast way the brain learns from just one event. Their 2026 review deals with behavioral timescale synaptic plasticity, in which a seconds-long window around a dendritic voltage surge lets synapses strengthen at once. The classic form works in milliseconds; life happens in seconds, and this form bridges the gap.
It builds and updates the place cells that map the world for the animal. The review focuses on the instructive signal that comes from the entorhinal cortex and sets off the surges. It also weighs proof that the same process works beyond the hippocampus. Learning in one shot is how animals live, so the way this works matters a great deal.
Catalog record
| CREATOR | Lucius K Wilmerding, Fox Gourianova, Christine Grienberger |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |