Macrophage SELENOP controls neutrophil homeostasis through redox stress regulation in Crohn's disease
Honggang Wang, Juan Wang, Wenliang Jiang, Chao Cheng, Shaoqi Cheng, Shuqiang Fu, Yi Zhang, Cuixia Liu, Jing Sun, Jie Zhao · 2026
Read Macrophage SELENOP controls neutrophil homeostasis through redox stress regulation in Crohn's disease by Honggang Wang, Juan Wang, Wenliang Jiang, Chao Cheng, Shaoqi Cheng, Shuqiang Fu, Yi Zhang, Cuixia Liu, Jing Sun, Jie Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13587815.txt.
Description
A selenium-carrying protein may keep gut inflammation in check, and a 2026 study by Honggang Wang and co-authors traces its role in Crohn's disease. Swollen Crohn's tissue is marked by crowds of neutrophils and heavy oxidative damage, and the team asked whether the protein, SELENOP, acts as a brake between immune cells.
Single-cell gene reading of colon samples showed the protein scarce in macrophages from inflamed tissue, and low levels tracked worse disease and more returns after surgery. In cell and mouse tests, losing the protein pushed macrophages into a stressed, more inflamed state through a known antioxidant pathway. A partner protein was found to tag SELENOP for destruction, while another switched its gene on.
Catalog record
| CREATOR | Honggang Wang, Juan Wang, Wenliang Jiang, Chao Cheng, Shaoqi Cheng, Shuqiang Fu, Yi Zhang, Cuixia Liu, Jing Sun, Jie Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |