Cellular redox status is linked to olfactory alterations in cognitive decline
Riikka Lampinen, Alexey M Afonin, Laura Mussalo, Simone Avesani, Tana Zavodna, Emily Feneberg, Zdenek Krejcik, Jan Topinka, Sweelin Chew, Heikki Löppönen, Tarja Malm, Rosalba Giugno, Anthony R White, Anne M Koivisto, Elina Penttilä, Katja M Kanninen · 2026
Read Cellular redox status is linked to olfactory alterations in cognitive decline by Riikka Lampinen, Alexey M Afonin, Laura Mussalo, Simone Avesani, Tana Zavodna, Emily Feneberg, Zdenek Krejcik, Jan Topinka, Sweelin Chew, Heikki Löppönen, Tarja Malm, Rosalba Giugno, Anthony R White, Anne M Koivisto, Elina Penttilä, Katja M Kanninen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13587812.txt.
Description
Riikka Lampinen and a large team link cell redox state in the nose to loss of smell in early cognitive decline. Loss of smell often appears early in Alzheimer disease, yet little is known about redox balance in the smell tissue of the nose. The team takes small biopsies of that tissue from healthy donors and from people with mild impairment or Alzheimer disease.
Protein surveys of the biopsies show changes in the energy parts of cells and in defenses against oxidative stress. Tests on cells grown from the biopsies add data on small RNA, energy carriers, and a key protective molecule. Smell test scores let the team tie the cell changes to real loss of smell. The work opens a window on early disease that can be reached without brain tissue.
Catalog record
| CREATOR | Riikka Lampinen, Alexey M Afonin, Laura Mussalo, Simone Avesani, Tana Zavodna, Emily Feneberg, Zdenek Krejcik, Jan Topinka, Sweelin Chew, Heikki Löppönen, Tarja Malm, Rosalba Giugno, Anthony R White, Anne M Koivisto, Elina Penttilä, Katja M Kanninen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |