A General Photoredox Platform for the Hydroarylation of Olefins
Yi-Lun Li, Johnny Z. Wang, David W. C. MacMillan · 2026
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Description
Yi-Lun Li, Johnny Wang, and David MacMillan report a general light-driven method for joining ring-shaped chemical groups to carbon chains. Their paper is from two thousand twenty-six. Such joins are a direct route to drug-like molecules. Past methods struggled to use the most common starting materials across the full range of chain types.
Their platform uses a halogen atom transfer step to free a reactive ring fragment under mild light. It then attaches that fragment across a double bond. The method works for chains with the bond at the end, in the middle, or doubled at one carbon. It also accepts a wide range of ring partners. The team shows uses such as adding heavy hydrogen and building ring-shaped chains.
Catalog record
| CREATOR | Yi-Lun Li, Johnny Z. Wang, David W. C. MacMillan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |