Cancer-associated fibroblasts in thyroid cancer stroma correlate with tumour progression and desmoplasia: a histopathological study
Markos Christidis, Andreas C. Lazaris, Polyxeni Nicolopoulou-Stamati, Evangelia Baliou, Athanasios Zafeirakis, Georgios Vilaras, Georgia-Eleni Thomopoulou · 2026
Read Cancer-associated fibroblasts in thyroid cancer stroma correlate with tumour progression and desmoplasia: a histopathological study by Markos Christidis, Andreas C. Lazaris, Polyxeni Nicolopoulou-Stamati, Evangelia Baliou, Athanasios Zafeirakis, Georgios Vilaras, Georgia-Eleni Thomopoulou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13587427.txt.
Description
Markos Christidis and colleagues examine the support tissue around thyroid tumors for signs of how the cancer will behave. Tumors grow in a bed of tissue called stroma, and fibroblasts roused by the cancer, known as cancer-associated fibroblasts, can feed its spread. Their 2026 study stained tissue from 85 thyroid cancer cases for two fibroblast markers and for the scar-like growth called desmoplasia, then matched the patterns to tumor features.
One marker, alpha-SMA, ran higher in men's samples, in tumors over a centimeter wide, and in tumors with aggressive traits. The second marker, FAP, tracked with the amount of desmoplasia present. That scar tissue itself, oddly, ran lower in the larger tumors. The authors read the fibroblast signs as companions of progression in thyroid cancer and as possible handles for sorting patients by risk.
Catalog record
| CREATOR | Markos Christidis, Andreas C. Lazaris, Polyxeni Nicolopoulou-Stamati, Evangelia Baliou, Athanasios Zafeirakis, Georgios Vilaras, Georgia-Eleni Thomopoulou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46184 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |