Human P301L tau expression in mice alters neuronal excitability independent of neurodegeneration
Katie L. Dunton, Hugo Monchal, Brie E. Achorn, Betty Mandé-Niedergang, Corinne Roucard, Yann Roche, Alexis Evrard, Frank S. Menniti · 2026
Read Human P301L tau expression in mice alters neuronal excitability independent of neurodegeneration by Katie L. Dunton, Hugo Monchal, Brie E. Achorn, Betty Mandé-Niedergang, Corinne Roucard, Yann Roche, Alexis Evrard, Frank S. Menniti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13587354.txt.
Description
Katie Dunton and co-authors studied mice carrying a human tau fault in a 2026 brain paper. Changes in the tau protein cause several diseases that kill brain cells, including Alzheimer's, but how the change first harms the brain is still murky.
The team used mice with the P301L tau variant, a model of frontotemporal dementia, and recorded brain signals from three to ten months of age. The mice showed stronger power in fast brain rhythms, most clearly in the hippocampus. This odd signal pattern appeared before heavy cell loss in the front of the brain. The finding hints that faulty tau disturbs brain wiring early, well before cells die.
Catalog record
| CREATOR | Katie L. Dunton, Hugo Monchal, Brie E. Achorn, Betty Mandé-Niedergang, Corinne Roucard, Yann Roche, Alexis Evrard, Frank S. Menniti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |