Molecular characterization of normal and physiologically suppressed human parathyroid glands at single-cell resolution
Timofey Glinin, Sergey Isaev, Anastasia Shubina, Igor Adameyko, Elham Khanafshar, Julie A Sosa, James Koh · 2026
Read Molecular characterization of normal and physiologically suppressed human parathyroid glands at single-cell resolution by Timofey Glinin, Sergey Isaev, Anastasia Shubina, Igor Adameyko, Elham Khanafshar, Julie A Sosa, James Koh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13586761.txt.
Description
Timofey Glinin and colleagues read single cells from human parathyroid glands to learn how healthy glands fall silent. These four small glands in the neck control blood calcium by releasing a hormone called PTH. When one gland grows a tumor and floods the body with hormone, the others quiet down, a state called suppression, and the reason was unclear. Their 2026 study sequenced close to eighty-four thousand cell nuclei from normal and suppressed glands.
Four cell types appeared, including one marked PDE10A that grew common in suppressed glands and one found only in active tissue. Suppressed glands also raised a scavenger protein, LRP2, and soaked up hormone from outside; blocking that scavenger in lab tissue let hormone flow again. Enzyme blockers split by gland state as well. The picture is of glands actively swallowing their own hormone to stay quiet.
Catalog record
| CREATOR | Timofey Glinin, Sergey Isaev, Anastasia Shubina, Igor Adameyko, Elham Khanafshar, Julie A Sosa, James Koh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76249 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |