Glomerular filtration rate estimation in nephrotic patients: creatinine and/or cystatin-C-based equations, or none of them?
Fabiola Carrara, Serenella Valaperta, Mariagrazia Alessio, Matias Trillini, Alessia Gennarini, Aura Crispino, Alessandro Villa, Tobia Peracchi, Daniela Cugini, Nadia Stucchi, Ilaria Pagani, Giuseppe Remuzzi, Piero Ruggenenti · 2026
Read Glomerular filtration rate estimation in nephrotic patients: creatinine and/or cystatin-C-based equations, or none of them? by Fabiola Carrara, Serenella Valaperta, Mariagrazia Alessio, Matias Trillini, Alessia Gennarini, Aura Crispino, Alessandro Villa, Tobia Peracchi, Daniela Cugini, Nadia Stucchi, Ilaria Pagani, Giuseppe Remuzzi, Piero Ruggenenti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13586628.txt.
Description
Fabiola Carrara and co-authors test formulas that estimate kidney function in patients with heavy protein loss in urine, in a 2026 study. Such estimates guide drug doses and care, but their accuracy in nephrotic patients, whose blood protein is low, was unknown. The team compare six formulas against a direct measure of filtration in fifty patients, sampled twice a year apart.
Formulas based on one marker alone overshot or undershot the true value. Bias grew as blood protein fell, whatever the urine protein level was. Only formulas that join both markers did acceptably, and only in patients with normal blood protein. Over a year, true filtration rose, but no formula captured that change. The authors advise direct measurement when blood protein is low, when dosing toxic drugs, or when judging change over time.
Catalog record
| CREATOR | Fabiola Carrara, Serenella Valaperta, Mariagrazia Alessio, Matias Trillini, Alessia Gennarini, Aura Crispino, Alessandro Villa, Tobia Peracchi, Daniela Cugini, Nadia Stucchi, Ilaria Pagani, Giuseppe Remuzzi, Piero Ruggenenti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |