A Tel1–Rad9 axis links DNA double-strand break end-tethering to repair pathway choice
Carlo Rinaldi, Federica Pagnotta, Renata Tisi, Maria Pia Longhese · 2026
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Description
Carlo Rinaldi, Federica Pagnotta, Renata Tisi, and Maria Pia Longhese published a 2026 study of broken DNA strands in yeast. The question is how cells keep the two ends of a break close, and how that choice sets the repair path. A break wakes two alarm hubs. One repair way needs the ends trimmed first. A helper protein starts that trim and keeps the ends tied.
The team found a variant of the first hub that helps cells which lack the helper. It sits at breaks more than the normal hub. It marks a guard protein more strongly, and that protein clumps with itself. That clump is the tie. Without clumping ability, the help fails. Artificial clumps, made by a chemical trick, restored the help. The hub variant steers repair toward the deep-matching way and cuts the loose-joining way.
Catalog record
| CREATOR | Carlo Rinaldi, Federica Pagnotta, Renata Tisi, Maria Pia Longhese |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |