Mechanistic Basis for 5-HT2AR Over 5-HT2BR Activation
Lingjie Tang, Xin Ji, Yumeng Wang, Dongmei Cao, Huiqiong Li, Licong He, Jianjun Cheng, Sheng Wang · 2026
Read Mechanistic Basis for 5-HT2AR Over 5-HT2BR Activation by Lingjie Tang, Xin Ji, Yumeng Wang, Dongmei Cao, Huiqiong Li, Licong He, Jianjun Cheng, Sheng Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13586193.txt.
Description
Lingjie Tang and seven co-authors published this study in 2026. It explains, at the level of molecular shape, why some compounds switch on one serotonin receptor but not its close cousin. The first receptor drives the effects sought in psychedelic-based mental health drugs. The second can harm heart valves.
The team mapped two side pockets in each receptor's binding site. Small differences in those pockets force compounds to sit at different angles, which changes the signal sent. They built new compounds across two chemical families that grip the pockets in the safer pattern. Frozen images of one compound bound to both receptors confirmed the design. The work gives drug makers a concrete map for building serotonergic drugs that keep the benefit and drop the heart risk.
Catalog record
| CREATOR | Lingjie Tang, Xin Ji, Yumeng Wang, Dongmei Cao, Huiqiong Li, Licong He, Jianjun Cheng, Sheng Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |