Epigallocatechin-3-Gallate, the green tea polyphenol suppresses expression of CD31 and VEGFR2 and enhances the chemotherapeutic potential of irinotecan in AOM/DSS model of colorectal cancer in mice
Sabana Sargam Rahman, Sukanya Baruah, Nabila Akhtara, Jaydeep Kumar Nath, Manuj Kumar Bharali · 2026
Read Epigallocatechin-3-Gallate, the green tea polyphenol suppresses expression of CD31 and VEGFR2 and enhances the chemotherapeutic potential of irinotecan in AOM/DSS model of colorectal cancer in mice by Sabana Sargam Rahman, Sukanya Baruah, Nabila Akhtara, Jaydeep Kumar Nath, Manuj Kumar Bharali (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13586132.txt.
Description
Rahman and four co-authors test a green tea compound against colon cancer in mice, in a paper published in two thousand twenty-six. The compound, called EGCG, was paired with the chemotherapy drug irinotecan to see whether the pair beats the drug alone.
Cancer was induced in the mice with two chemicals, and after sixteen weeks the team examined tumors, tissue, and gene activity. The combination cut tumor counts, eased symptoms, improved tissue appearance, and lowered markers tied to blood vessel growth that feeds tumors, including CD31 and VEGFR2. It also reduced liver injury linked to the drug. The results suggest the tea compound could make this chemotherapy stronger and gentler at once, at least in this animal model.
Catalog record
| CREATOR | Sabana Sargam Rahman, Sukanya Baruah, Nabila Akhtara, Jaydeep Kumar Nath, Manuj Kumar Bharali |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |