Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease
Jagan A Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M Bekris, Maria Khrestian, Frank P DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B Leverenz, Yuan Hou, Feixiong Cheng, Stephen M Rao · 2026
Read Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease by Jagan A Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M Bekris, Maria Khrestian, Frank P DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B Leverenz, Yuan Hou, Feixiong Cheng, Stephen M Rao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13586066.txt.
Description
Jagan Pillai and twelve co-authors hunt for early warning proteins in brain fluid and blood, in a study dated 2026. Their subjects are older adults who still think normally but face raised risk of Alzheimer disease. Signals that precede decline could open a window for early care.
The team followed 118 adults aged sixty-five to eighty for two years, measuring over a thousand proteins in spinal fluid and blood at both visits. About a quarter already showed early disease signs, and over half carried a known risk gene. Statistical models linked certain inflammation-related proteins to later thinking decline. Network methods picked out hub proteins and pathways, and trimmed panels were cross-checked on a second platform. The spinal fluid signals are the paper's main focus.
Catalog record
| CREATOR | Jagan A Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M Bekris, Maria Khrestian, Frank P DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B Leverenz, Yuan Hou, Feixiong Cheng, Stephen M Rao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |