Digoxin Derivative BD-8 Attenuates Oxidative Stress and Neuroinflammation in an LPS-Induced Experimental Model
Vitória Karolina Brandão Souza, Davi Azevedo Ferreira, Antônio Pereira Ribeiro Arantes, Elton de Sá Figueiredo, Millena Ferreira Rodrigues Fonseca, Pâmela Yasmin de Oliveira Ferreira, Martina Raissa Ribeiro, Paulo César Ghedini, Andreza Amália de Freitas Ribeiro, José Augusto Ferreira Perez Villar, Maira de Castro Lima, Israel José Pereira Garcia, Hérica L Santos, Cristoforo Scavone, Sandra Rodrigues Mascarenhas, Jacqueline Alves Leite · 2026
Read Digoxin Derivative BD-8 Attenuates Oxidative Stress and Neuroinflammation in an LPS-Induced Experimental Model by Vitória Karolina Brandão Souza, Davi Azevedo Ferreira, Antônio Pereira Ribeiro Arantes, Elton de Sá Figueiredo, Millena Ferreira Rodrigues Fonseca, Pâmela Yasmin de Oliveira Ferreira, Martina Raissa Ribeiro, Paulo César Ghedini, Andreza Amália de Freitas Ribeiro, José Augusto Ferreira Perez Villar, Maira de Castro Lima, Israel José Pereira Garcia, Hérica L Santos, Cristoforo Scavone, Sandra Rodrigues Mascarenhas, Jacqueline Alves Leite (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13586031.txt.
Description
Vitória Karolina Brandão Souza and a large team test a safer cousin of the heart drug digoxin against brain inflammation. The new compound, called BD-8, comes from the same plant steroid family but was built to spare healthy cells. In their 2026 study, they checked it in lab-grown brain and immune cells, then in animals given a bacterial toxin that sparks brain inflammation and slows movement.
BD-8 harmed cultured cells only at doses far above those that hurt cells with plain digoxin. In the animals, it kept movement near normal, cut a marker of fat damage in two brain regions, and tuned the brain's own antioxidant enzymes. It also lowered the inflammatory signal IL-6 without touching a growth factor for neurons. Blood markers for heart, liver, and kidney stayed steady, which supports its safety case.
Catalog record
| CREATOR | Vitória Karolina Brandão Souza, Davi Azevedo Ferreira, Antônio Pereira Ribeiro Arantes, Elton de Sá Figueiredo, Millena Ferreira Rodrigues Fonseca, Pâmela Yasmin de Oliveira Ferreira, Martina Raissa Ribeiro, Paulo César Ghedini, Andreza Amália de Freitas Ribeiro, José Augusto Ferreira Perez Villar, Maira de Castro Lima, Israel José Pereira Garcia, Hérica L Santos, Cristoforo Scavone, Sandra Rodrigues Mascarenhas, Jacqueline Alves Leite |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42269 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |