Case Report: Neuroendocrine-low POU2F3-positive small cell lung cancer presenting as a diagnostically unstable thoracic malignancy
Ying Ma, Wenlong Chen, Fangfei Guo, Songchen Han · 2026
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Description
Ma, Chen, Guo, and Han reported a hard-to-classify lung cancer case in twenty twenty-six. Small cell lung cancer has subtypes; one, marked by the protein POU2F3, makes few of the usual neuroendocrine markers, so small biopsies can mislead. Their patient was a sixty-one-year-old man with a high-grade tumor in the left upper lung lobe.
Two biopsies from different sites both suggested small cell carcinoma, but marker patterns varied between samples and reviews. POU2F3 staining supported the subtype assignment. While classification stayed unresolved, the team used a chemotherapy plus immunotherapy bridge. After four cycles the tumor shrank markedly, and a multidisciplinary decision led to surgery. The removed tissue showed a complete pathological response. Later cycles followed, and surveillance imaging in twenty twenty-six showed no recurrence, with no tumor DNA in blood. The authors stress one case sets no standard.
Catalog record
| CREATOR | Ying Ma, Wenlong Chen, Fangfei Guo, Songchen Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |