High resolution ES-DMA quantifies AAV capsid DNA content by electrical mobility to mass correlation
Preston Dennett, Lohra M Young, Benjamin E Draper, Jerome Schmitt, Martin Jarrold, Luis Javier Perez-Lorenzo · 2026
Read High resolution ES-DMA quantifies AAV capsid DNA content by electrical mobility to mass correlation by Preston Dennett, Lohra M Young, Benjamin E Draper, Jerome Schmitt, Martin Jarrold, Luis Javier Perez-Lorenzo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13585554.txt.
Description
Preston Dennett and colleagues show a bench-top way to size the DNA load inside gene-therapy virus shells. Recombinant adeno-linked virus shells are the top way to ferry gene cures, yet pure batches hold empty, half-full, and over-full shells next to full ones. Such duds raise cost, cut cure power, and may add risk at high doses.
High-res electrospray mobility sizing takes tiny drops and sizes bits to the angstrom, which is fine enough to tell full shells from duds by how they drift in an electric field. Set beside mass spectrometry, drift tracked mass in a near-straight line. The method can thus sort and count empty, full, and half-full shells fast in drug plants.
Catalog record
| CREATOR | Preston Dennett, Lohra M Young, Benjamin E Draper, Jerome Schmitt, Martin Jarrold, Luis Javier Perez-Lorenzo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |