Median effective dose and 95% effective dose of oliceridine combined with ciprofol for painless gastroscopy: a dose-finding study based on Dixon’s up-and-down method
Xikun Sun, Pei Song, Bin Zou, Yimeng Zhuang, Xiaohang Han, Jianyu Zu, Yugang Diao · 2026
Read Median effective dose and 95% effective dose of oliceridine combined with ciprofol for painless gastroscopy: a dose-finding study based on Dixon’s up-and-down method by Xikun Sun, Pei Song, Bin Zou, Yimeng Zhuang, Xiaohang Han, Jianyu Zu, Yugang Diao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13585511.txt.
Description
Xikun Sun and colleagues find the right dose of the pain drug oliceridine, paired with the sedative ciprofol, for painless stomach scope exams. Doses were tuned separately for men and women with the Dixon up-and-down method, where each patient's dose moves up or down based on the last patient's response. A set dose of ciprofol followed the test dose.
Twenty-nine men and thirty-two women finished. The median effective dose was lower in women, about thirteen micrograms per kilo, than in men, about seventeen. The ninety-five percent doses were about eighteen and twenty-one respectively. Side effect rates did not differ by sex. The values give clinics a sex-aware starting dose for the pairing.
Catalog record
| CREATOR | Xikun Sun, Pei Song, Bin Zou, Yimeng Zhuang, Xiaohang Han, Jianyu Zu, Yugang Diao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |