Synergistic inhibition of Notch signaling and forced cell cycle re-entry drive Müller glia reprogramming in uninjured mouse retina
Baoshan Liao, Chengshang Lyu, Yuqing Jiang, Shanggong Liu, Waiho Wong, Jiadong Zhang, Hoyin Tsang, Junxi Xie, Lingxi Chen, Qinrong Zhang, Wenjun Xiong, Xiaorong Liu, Baoshan Liao, Chengshang Lyu, Yuqing Jiang, Shanggong Liu, Waiho Wong, Jiadong Zhang, Hoyin Tsang, Junxi Xie, Lingxi Chen, Qinrong Zha · 2026
Read Synergistic inhibition of Notch signaling and forced cell cycle re-entry drive Müller glia reprogramming in uninjured mouse retina by Baoshan Liao, Chengshang Lyu, Yuqing Jiang, Shanggong Liu, Waiho Wong, Jiadong Zhang, Hoyin Tsang, Junxi Xie, Lingxi Chen, Qinrong Zhang, Wenjun Xiong, Xiaorong Liu, Baoshan Liao, Chengshang Lyu, Yuqing Jiang, Shanggong Liu, Waiho Wong, Jiadong Zhang, Hoyin Tsang, Junxi Xie, Lingxi Chen, Qinrong Zha (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13585425.txt.
Description
Baoshan Liao leads a team on reprogramming eye support cells in mice. Their study from twenty twenty-six deals with Muller glia in the retina. In fish, these cells regrow lost nerve cells after harm.
In mammals, that regrowth is blocked and loss is final. Most new daughter cells keep glial fate in past tries. High Notch signals may be the brake on nerve fate. Cutting Notch alone gave slight nerve conversion sans growth. Joining it with forced cell cycle entry worked far better. New nerve marks showed in daughter cells.
Catalog record
| CREATOR | Baoshan Liao, Chengshang Lyu, Yuqing Jiang, Shanggong Liu, Waiho Wong, Jiadong Zhang, Hoyin Tsang, Junxi Xie, Lingxi Chen, Qinrong Zhang, Wenjun Xiong, Xiaorong Liu, Baoshan Liao, Chengshang Lyu, Yuqing Jiang, Shanggong Liu, Waiho Wong, Jiadong Zhang, Hoyin Tsang, Junxi Xie, Lingxi Chen, Qinrong Zha |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 123 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |