Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites
Deborah Maus, Elyzana Putrianti, Tobias Hoffmann, Michael Laue, Frank Seeber, Martin Blume, Bavesh D Kana, Deborah Maus, Elyzana Putrianti, Tobias Hoffmann, Michael Laue, Frank Seeber, Martin Blume · 2026
Read Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites by Deborah Maus, Elyzana Putrianti, Tobias Hoffmann, Michael Laue, Frank Seeber, Martin Blume, Bavesh D Kana, Deborah Maus, Elyzana Putrianti, Tobias Hoffmann, Michael Laue, Frank Seeber, Martin Blume (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13585424.txt.
Description
Deborah Maus and co-authors screened a box of candidate drugs against the dormant stage of a common parasite, in a study published in 2026. They found a weak spot in its power plant. The parasite infects a quarter to a third of humanity. It hides in brain and muscle cysts, causing grave illness when immunity fails. Existing drugs kill only its fast-growing form.
Using human muscle cells grown in the lab, the team tested compounds against cyst-stage parasites. The test strains were bred to resist standard care. Several compounds hit both stages at once. Chemical tracing then showed the active ones strike a key complex in the parasite's energy machinery. The data suggest even dormant forms lean on that machinery to live. Drug hunters can exploit that dependence.
Catalog record
| CREATOR | Deborah Maus, Elyzana Putrianti, Tobias Hoffmann, Michael Laue, Frank Seeber, Martin Blume, Bavesh D Kana, Deborah Maus, Elyzana Putrianti, Tobias Hoffmann, Michael Laue, Frank Seeber, Martin Blume |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |