Demonstration of 23-Gene Expression Profile Test Utility Within PRAME Immunohistochemistry Results: A Case Series
Gregory A. Hosler, Matthew S. Goldberg, Etan Marks · 2026
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Description
Gregory A. Hosler, Matthew S. Goldberg, and Etan Marks present eight hard-to-call skin cases in this 2026 series. The growths at issue are melanocytic, meaning they arise from pigment cells, and some are melanoma, a dangerous skin cancer, while others are harmless moles. A stain test called PRAME often helps, yet its readings can clash or stay unclear, leaving experts split.
Each case drew four or five separate expert opinions. The team then ran a 23-gene test, which reads the activity of a set of genes in the tissue, to see if it could tip the balance. In cases where the stain was muddy or conflicting, the gene results pushed the final call up or down in risk. The authors offer the test as a tiebreaker, not a replacement for expert review.
Catalog record
| CREATOR | Gregory A. Hosler, Matthew S. Goldberg, Etan Marks |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22408 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |