Erythrocytes as immunomodulators in trauma: orchestrating clearance pathways, inflammation, and organ injury
Xuru Qian, Linglong Chen, Renxian Gao, Yue Lin, Kaihuai Wu, Xiaojie Wang, Yingying Jiang · 2026
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Description
Red blood cells are usually cast as passive oxygen trucks, but Xuru Qian and six co-authors argue they also police the immune response after trauma. Their 2026 narrative review reframes the cells as active modulators in the chaos that follows severe injury. That chaos, left unchecked, drives much of trauma's death and disability.
In the healthy body, red cells help clear immune complexes and worn-out material in an orderly way. After injury they change their surface, shed danger signals, and trade messages with immune cells. When those pathways run well, they support cleanup and repair. When they jam or overfire, the same cells feed inflammation and organ damage. The review draws on patient studies, animal work, and related diseases to map this double role, and it flags where the balance tips.
Catalog record
| CREATOR | Xuru Qian, Linglong Chen, Renxian Gao, Yue Lin, Kaihuai Wu, Xiaojie Wang, Yingying Jiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |