Improved nucleic acid sensing, exemplified using pure target DNA sequences, by MO capture probes compared to DNA capture probes, as revealed from PO2−, PO3− and nucleobase mass peaks
Budhaditya Bhattacharya, Jayanta Kundu, Aratrika Ghosal, Asmita Paul, Md Qasim, Sirsha Dattasarma, Tanushree Mana, Subhra Sankar Dutta, Surajit Sinha, Sayan Dey, Swati Dasgupta, Rupa Mukhopadhyay · 2026
Read Improved nucleic acid sensing, exemplified using pure target DNA sequences, by MO capture probes compared to DNA capture probes, as revealed from PO2−, PO3− and nucleobase mass peaks by Budhaditya Bhattacharya, Jayanta Kundu, Aratrika Ghosal, Asmita Paul, Md Qasim, Sirsha Dattasarma, Tanushree Mana, Subhra Sankar Dutta, Surajit Sinha, Sayan Dey, Swati Dasgupta, Rupa Mukhopadhyay (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13584705.txt.
Description
Budhaditya Bhattacharya and co-authors build a gene sensor with a tougher net for catching target DNA. Standard sensors use DNA capture probes, which enzymes chew up and which can blur single-letter mismatches. The team swaps in morpholino probes, synthetic strands that resist those enzymes, and mounts them on spherical nanoparticles to widen the catching surface.
A mass spectrometry method read the surface after targets were offered. Fully matching DNA lit up the telltale phosphate peaks, while mismatched and absent targets did not. The morpholino sensor beat the DNA version at telling true matches from near misses, even for the trickiest single-letter changes. Such changes drive many diseases, so sharper sorting matters for diagnostics.
Catalog record
| CREATOR | Budhaditya Bhattacharya, Jayanta Kundu, Aratrika Ghosal, Asmita Paul, Md Qasim, Sirsha Dattasarma, Tanushree Mana, Subhra Sankar Dutta, Surajit Sinha, Sayan Dey, Swati Dasgupta, Rupa Mukhopadhyay |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |