Identification, Structure–Activity Relationship (SAR), and Biological Evaluation of New Chemical Series as Malaria Parasite PfGCN5 Bromodomain Inhibitors
Pedro Martin-Acosta, Abbas H. K. Al Temimi, Luma Godoy Magalhaes, Juan Salamanca-Viloria, Jose Ignacio Martin Hernando, Ana I. Villegas, Virginia Franco Hidalgo, Joel McMillan, Andrew Plater, Mark Anderson, Raquel Gabarro, Felix Calderon, Maria Santos Martinez-Martinez, Emiliana D’Oria, Jair L. Siqu · 2026
Read Identification, Structure–Activity Relationship (SAR), and Biological Evaluation of New Chemical Series as Malaria Parasite PfGCN5 Bromodomain Inhibitors by Pedro Martin-Acosta, Abbas H. K. Al Temimi, Luma Godoy Magalhaes, Juan Salamanca-Viloria, Jose Ignacio Martin Hernando, Ana I. Villegas, Virginia Franco Hidalgo, Joel McMillan, Andrew Plater, Mark Anderson, Raquel Gabarro, Felix Calderon, Maria Santos Martinez-Martinez, Emiliana D’Oria, Jair L. Siqu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13584588.txt.
Description
Pedro Martin-Acosta and co-authors screen a huge compound library for blockers of a malaria parasite protein, in a study from two thousand twenty-six. The target helps the parasite switch genes on and off. About forty-eight thousand compounds from a company collection were tested against it.
Six early hits passed the first bar, and two were carried into deeper profiling. Chemistry work and computer modeling sharpened two leads to strong potency against the target itself. Yet neither lead killed the parasite well in cells. The authors warn the target may prove a hard road for new malaria drugs, pending more work.
Catalog record
| CREATOR | Pedro Martin-Acosta, Abbas H. K. Al Temimi, Luma Godoy Magalhaes, Juan Salamanca-Viloria, Jose Ignacio Martin Hernando, Ana I. Villegas, Virginia Franco Hidalgo, Joel McMillan, Andrew Plater, Mark Anderson, Raquel Gabarro, Felix Calderon, Maria Santos Martinez-Martinez, Emiliana D’Oria, Jair L. Siqu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 153 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |